非环丁烷型胸苷光产物是紫外线照射DNA构象变化中的关键事件。
Thymidine photoproducts of non-cyclobutane type as a crucial event in the conformation of UV-irradiated DNA.
作者信息
Lang H, Birch-Hirschfeld E, Zimmer C
出版信息
Acta Biol Med Ger. 1979;38(9):1233-7.
PMID:550665
Abstract
The UV-light induced conformational effects in deoxyoligonucleotides and polynucleotides have been analyzed by CD measurements and isolation of the photoproducts. The results demonstrate that the essential photoproduct formed on irradiation of thymidylyl-thymidine at 254 nm is of non-cyclobutane type and may be correlated to the primary photoproduct formed in DNAs at low doses Formation of thymine dimers of cyclobutane-type structure appears to be a secondary product generated by treatment with formic acid.
摘要
通过圆二色性测量和光产物的分离，对紫外线诱导的脱氧寡核苷酸和多核苷酸的构象效应进行了分析。结果表明，在254nm波长照射胸苷酰-胸苷时形成的主要光产物是非环丁烷型的，并且可能与低剂量DNA中形成的初级光产物相关。环丁烷型结构的胸腺嘧啶二聚体的形成似乎是用甲酸处理产生的次级产物。
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