Barbieri D, De Brito T, Hoshino S, Nascimento O B, Martins Campos J V, Quarentei G, Marcondes E
Arch Dis Child. 1970 Aug;45(242):466-72. doi: 10.1136/adc.45.242.466.
Eleven symptom-free children with infestation by but without other diseases were studied by absorption tests and jejunal biopsy. Lipiodol and d-xylose tests showed a mild degree of malabsorption. Light microscopy showed no tissue invasion in the jejunal mucosa. The number and appearance of the villi were normal or almost normal, but the lamina propria was usually infiltrated by inflammatory cells. Electron microscopy showed an increased mucoid coat of the epithelial cells, branching and gaps in the microvilli, an increased number of cytoplasmic dense bodies, and intercellular spaces infiltrated with lamina propria inflammatory cells. Biochemical and histochemical studies of acid phosphatases, alkaline phosphatases, and succinic dehydrogenase showed no differences in enzyme activity of the jejunal epithelia before and after treatment. It is suggested that the malabsorption which occurs in giardiasis depends on several factors, such as blockade of the mucosa by the parasite, nutritional competition between host and parasite, and changes in the jejunal mucosa due to the presence of protozoa.
对11名无症状但感染了[寄生虫名称未给出]且无其他疾病的儿童进行了吸收试验和空肠活检研究。碘油和d-木糖试验显示有轻度吸收不良。光镜检查显示空肠黏膜无组织侵袭。绒毛的数量和外观正常或几乎正常，但固有层通常有炎症细胞浸润。电镜检查显示上皮细胞黏液层增厚、微绒毛分支和间隙、胞质致密体数量增加以及固有层炎症细胞浸润的细胞间隙。对酸性磷酸酶、碱性磷酸酶和琥珀酸脱氢酶的生化和组织化学研究表明，治疗前后空肠上皮的酶活性无差异。提示贾第虫病中发生的吸收不良取决于多种因素，如寄生虫对黏膜的阻塞、宿主与寄生虫之间的营养竞争以及原生动物存在导致的空肠黏膜变化。
