[普利亚地区的α地中海贫血。二、巴氏血红蛋白的新生儿筛查]
[Alpha-thalassemia in Puglia. II. Neonatal screening for Bart's hemoglobin].
作者信息
Izzo P, Pasculli D, Schonauer S, Mudoni A, De Mattia D, Constantino R, Melpignano A, Saccia M
出版信息
Boll Soc Ital Biol Sper. 1979 Apr 15;55(7):703-8.
550 blood specimens from the umbilical cord of newborn babies from Apulia have been screened in order to detect Hb Bart's. The electrophoresis of the haemoglobin by Cellogel (Tris Glycine pH 8.6) carried out on the 550 specimens have revealed in 43 variable quantities of Hb Bart's: 34 cases (6,18%) showed non measurable quota, whereas in the other 9 cases (1,63%) Hb Bart's varied from 2,19% to 26%. The haemoglobin biosynthesis "in vitro" of the baby presenting 26% of Hb Bart's has been reported.
为检测Hb Bart's，对来自普利亚地区新生儿脐带的550份血样进行了筛查。在这550份样本上通过Cellogel（Tris甘氨酸pH 8.6）进行血红蛋白电泳，结果显示43份样本中有数量不等的Hb Bart's：34例（6.18%）显示含量不可测，而其他9例（1.63%）中Hb Bart's含量从2.19%到26%不等。报告了Hb Bart's含量为26%的婴儿的血红蛋白“体外”生物合成情况。
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