Tyrkkö J, Viljanto J
Ann Chir Gynaecol Fenn. 1975;64(5):288-91.
Clinical and histopathological data were compared in a series of 59 patients with Dupuytren's contracture (DC) from the years 1946-1971 in order to clarify whether histopathological findings were in accordance with the clinical development of the disease. All well known histopathological features were inspected. The most valuable prognostic sign seemed to be the appearance of several active nodules, indicating rather rapid development of DC, with a high frequency of postoperative recurrence in these patients. Lack of active nodules did not exclude this possibility but made it less likely. Other occasional findings typical of DC such as the number of mitoses, microhaemorrhages, perivascular lymphocytic infiltrations and hypertrophied corpuscles of Vater-Paccini seemed to be of minor prognostic value. Mucopolysaccharides from DC tissue showed metachromasia with toluidine blue did not stain with HID-AB (high iron diamine-alcian blue) as HID positive in specimens preserved embedded in paraffin blocks for several years.
为了阐明组织病理学发现是否与疾病的临床发展相符，对1946年至1971年间的59例杜普伊特伦挛缩症（DC）患者的临床和组织病理学数据进行了比较。检查了所有众所周知的组织病理学特征。最有价值的预后指标似乎是出现多个活跃结节，这表明DC发展相当迅速，这些患者术后复发频率较高。没有活跃结节并不排除这种可能性，但可能性较小。DC的其他偶尔发现，如有丝分裂数量、微出血、血管周围淋巴细胞浸润和 Vater-Paccini 小体肥大，似乎预后价值较小。DC组织中的粘多糖用甲苯胺蓝显示异染性，在保存在石蜡块中数年的标本中，用高铁二胺-阿尔辛蓝（HID-AB）染色时不呈HID阳性。
