Topical timolol in open-angle glaucoma.

Timolol theraphy was started in 37 patients with open-angle glaucoma whose intraocular pressure was inadequately controlled with maximum medical theraphy or who were having side effects with conventional medication. The intraocular pressure was substantially reduced by timolol in most of the patients, and there were relatively few side effect. A slight decrease in the pulse rate occured in some patients. The pressure-lowering effect was additive to that of other medications the patients were receiving, and was particularly useful in 13 of the 16 patients whose intraocular pressure had previously been inadequately controlled by maximum medical theraphy. The pressure-lowering effect appeared to be well sustained in most patients, although the pressure rose slightly in some.