Schneider B F, Norton S
Neurobehav Toxicol. 1979 Fall;1(3):193-7.
Rats were exposed on gestational day 15 to 125 r X-irradiation, a treatment known to severely alter brain morphology. At 4-6 weeks of age the behavior of these animals was studied using two methods: (1) measurement of circadian locomotor activity, (2) photographic analysis of behavioral acts. The circadian locomotor activity of irradiated rats was similar to that of controls tested individually or as groups in a residential unit. After morphine sulfate, 2 mg/kg, the increase in locomotor activity was greater for the irradiated than control groups. Successive frames of photographic film were analyzed to determine the frequency, duration, sequencing of behavioral acts. No significant differences were present in these parameters of behavioral acts of control and irradiated rats. After morphine, irradiated rats showed a greater increase than controls in frequency and initiations of some behavioral acts, and these acts were more randomly dispersed in the sequences of acts. In this experiment activity was little affected by an agent which severely alters brain morphology, but the latent behavioral effects of the permanent brain damage became manifest, when the testing situation included challenge with a low dose of a drug which caused hyperactivity.
在妊娠第15天，将大鼠暴露于125伦琴的X射线照射下，这种处理已知会严重改变大脑形态。在4至6周龄时，使用两种方法研究这些动物的行为：（1）测量昼夜节律运动活动，（2）对行为动作进行摄影分析。照射大鼠的昼夜节律运动活动与在居住单元中单独或成组测试的对照组相似。给予2mg/kg硫酸吗啡后，照射组大鼠运动活动的增加幅度大于对照组。分析摄影胶片的连续帧以确定行为动作的频率、持续时间和顺序。对照组和照射组大鼠行为动作的这些参数没有显著差异。注射吗啡后，照射组大鼠在某些行为动作的频率和起始方面比对照组有更大的增加，并且这些动作在动作序列中分布得更随机。在本实验中，一种严重改变大脑形态的因素对活动影响很小，但当测试情况包括用低剂量引起多动的药物进行激发时，永久性脑损伤的潜在行为影响就显现出来了。
