Seifert J, Ganser R, Pfleiderer A, Brendel W
Klin Monbl Augenheilkd. 1979 Dec;175(6):795-8.
The absorption and transport pathways of Conjunctisan A were determined, and its mode of action clarified, by means of radioactive labeling. A dose of 0.5 ml of this drug, labeled with I131, was applied to the conjunctival sacs of rats and rabbits. After six hours there was highly significant enrichment in the ocular tissues. The highest degree of enrichment was found in the uvea, i.e., the ciliary body, choroid and retina. However, there was also moderate enrichment in the lens and the vitreous. It was proved immunologically that the radioactivity was identical with the original Conjunctisan A molecule. In particular, it as demonstrated that the enriched Conjunctisan A in the aqueous humor precipitates with the specific antibody.
通过放射性标记确定了结膜菌素A的吸收和转运途径，并阐明了其作用方式。将0.5毫升用I131标记的这种药物滴入大鼠和家兔的结膜囊。6小时后，眼部组织出现高度显著的富集。在葡萄膜（即睫状体、脉络膜和视网膜）中发现富集程度最高。然而，晶状体和玻璃体中也有中度富集。通过免疫学方法证明放射性与原始的结膜菌素A分子相同。特别是，已证明房水中富集的结膜菌素A能与特异性抗体沉淀。
