Papanicolaou N, Mountokalakis T, Palassides A, Paris M, Bariety J, Papavassiliou J, Merikas G, Milliez P
Prostaglandins Med. 1979 Jul;3(1):47-51. doi: 10.1016/0161-4630(79)90015-6.
Substances having the chromatographic behaviour and the bioassay properties of prostaglandins (PGE and PGF) were detected in the urine of 30 patients with kidney disease and 15 healthy subjects. The mean urinary PGE and PGF values in 15 patients with chronic glomerular disease or nephrosclerosis were significantly lower than those of 15 patients with chronic pyelonephritis and other forms of chronic interstitial nephritis, polycystic kidney disease, obstructive nephropathy or diuretic phase of acute renal failure, and of the mean PGE and PGF values found in the healthy subjects. It was suggested that in contrast to disease affecting primarily the renal medulla, chronic glomerular disease and nephrosclerosis are accompanied by a decrease of renal prostaglandin synthesis and/or release.
在30例肾病患者及15名健康受试者的尿液中检测到了具有前列腺素（PGE和PGF）色谱行为及生物测定特性的物质。15例慢性肾小球疾病或肾硬化患者的尿PGE和PGF平均水平显著低于15例慢性肾盂肾炎及其他形式的慢性间质性肾炎、多囊肾病、梗阻性肾病或急性肾衰竭利尿期患者，也低于健康受试者的PGE和PGF平均水平。有人提出，与主要影响肾髓质的疾病相反，慢性肾小球疾病和肾硬化伴有肾前列腺素合成和/或释放的减少。
