Mammalian hexokinases: a system for the study of co-operativity in monomeric enzymes.
作者信息
Cornish-Bowden A, Connolly B A, Gregoriou M, Holroyde M J, Storer A C, Trayer I P
出版信息
Arch Biol Med Exp. 1979 Dec;12(5):581-5.
PMID:552244
Abstract
Kinetic and structural studies have been carried out of two isoenzymes of hexokinase from the rat, hexokinase II and glucokinase. Although both enzymes are monomeric, hexokinase II has a molecular weight double that of glucokinase and resembles a dimer of glucokinase. The co-operativity of glucokinase, which is not observed for hexokinase II, appears to be kinetic in origin rather than the consequence of ineractions between distinct glucose-binding sites.
摘要
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