Gangarosa L P, Merchant H W, Park N H, Hill J M
Methods Find Exp Clin Pharmacol. 1979 Jun;1(2):105-9.
In clinical trials on six patients the antiviral drug idoxuridine (Stoxil) was applied by anodal (+) iontophoresis to 14 recurrent herpes labialis lesions. Results were characterized by immediate relief of discomfort and swelling, rapid appearance and coalescence of vesicles, minimal or no spread of the lesions, and accelerated healing with minimal or no scab. These encouraging trials indicate that a full-scale, double-blind, controlled clinical study should be carried out to determine whether iontophoresis is the optimal method of applying idoxuridine to the surface lesions caused by herpesvirus.
在针对6名患者的临床试验中，通过阳极（+）离子导入法将抗病毒药物碘苷（疱疹净）应用于14处复发性唇疱疹病灶。结果表现为不适感和肿胀立即缓解，水疱迅速出现并融合，病灶极少扩散或不扩散，愈合加速且结痂极少或无结痂。这些令人鼓舞的试验表明，应开展一项全面的双盲对照临床研究，以确定离子导入法是否是将碘苷应用于疱疹病毒引起的表面病灶的最佳方法。
