• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Pc 1杜阿尔特，一种人类脑蛋白的常见多态性，及其与抑郁症和多发性硬化症的关系。

Pc 1 Duarte, a common polymorphism of a human brain protein, and its relationship to depressive disease and multiple sclerosis.

作者信息

Comings D E

出版信息

Nature. 1979 Jan 4;277(5691):28-32. doi: 10.1038/277028a0.

DOI:10.1038/277028a0
PMID:552595
Abstract

Pc 1 Duarte, a common variant of a human brain-specific protein, is present in one-third of the control population and has a gene frequency of 0.17. There was a significantly increased frequency of mutant heterozygotes and homozygotes among individuals with depressive disease. This is consistent with a model in which Pc 1 Duarte is the major gene in depressive disease, acting in conjunction with an environmental threshold effect.

摘要

Pc 1杜阿尔特是一种人类大脑特异性蛋白质的常见变体，在三分之一的对照人群中存在，基因频率为0.17。在患有抑郁症的个体中，突变杂合子和纯合子的频率显著增加。这与一种模型一致，即Pc 1杜阿尔特是抑郁症的主要基因，与环境阈值效应共同起作用。

相似文献

1
Pc 1 Duarte, a common polymorphism of a human brain protein, and its relationship to depressive disease and multiple sclerosis.Pc 1杜阿尔特，一种人类脑蛋白的常见多态性，及其与抑郁症和多发性硬化症的关系。
Nature. 1979 Jan 4;277(5691):28-32. doi: 10.1038/277028a0.
2
Dopamine uptake sites, labelled with [3H]GBR12935, in brain samples from depressed suicides and controls.用[3H]GBR12935标记的多巴胺摄取位点，存在于抑郁症自杀者和对照组的脑样本中。
Eur Neuropsychopharmacol. 1997 Nov;7(4):247-52. doi: 10.1016/s0924-977x(97)00423-9.
3
Association of the serotonin transporter promoter polymorphism with suicidal behavior.血清素转运体启动子多态性与自杀行为的关联。
Mol Psychiatry. 2003 Nov;8(11):899-900. doi: 10.1038/sj.mp.4001381.
4
Relationship between HLA-DRB1 polymorphism and susceptibility or resistance to multiple sclerosis in Caucasians: a meta-analysis of non-family-based studies.高加索人群 HLA-DRB1 多态性与多发性硬化易感性或抗性的关系：基于非家系研究的荟萃分析。
Autoimmun Rev. 2011 Jun;10(8):474-81. doi: 10.1016/j.autrev.2011.03.003. Epub 2011 Apr 2.
5
Developmental regulation of phosphoprotein gene expression in the caudate-putamen of rat: an in situ hybridization study.
Neuroscience. 1992 Nov;51(1):65-75. doi: 10.1016/0306-4522(92)90471-d.
6
An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms.
Mol Psychiatry. 1998 Sep;3(5):449-51. doi: 10.1038/sj.mp.4000424.
7
N-methyl-D-aspartate receptor 1 in the caudate-putamen nucleus: ultrastructural localization and co-expression with sorcin, a 22,000 mol. wt calcium binding protein.尾状核-壳核中的N-甲基-D-天冬氨酸受体1：超微结构定位以及与22,000分子量钙结合蛋白索肌动蛋白的共表达
Neuroscience. 1999 Apr;90(1):107-17. doi: 10.1016/s0306-4522(98)00440-0.
8
Endogenous phosphorylation in vitro: selective effects of sacrifice methods on specific brain proteins.体外内源性磷酸化：处死方法对特定脑蛋白的选择性影响。
Brain Res. 1978 Jan 13;139(2):366-73. doi: 10.1016/0006-8993(78)90938-1.
9
Prodynorphin mRNA expression is increased in the patch vs matrix compartment of the caudate nucleus in suicide subjects.在自杀者中，强啡肽原mRNA表达在尾状核的斑块与基质区室中增加。
Mol Psychiatry. 1997 Oct-Nov;2(6):495-500. doi: 10.1038/sj.mp.4000319.
10
Glial cell line-derived neurotrophic factor in the substantia nigra from control and parkinsonian brains.
Neurosci Lett. 2001 Mar 16;300(3):179-81. doi: 10.1016/s0304-3940(01)01577-4.

引用本文的文献

1
Study on nuclear and cytoplasmic genome expression in wheat by two-dimensional gel electrophoresis : 1. First results on 18 alloplasmic lines.小麦核质基因组表达的二维凝胶电泳研究：1. 18 种异质系的初步结果。
Theor Appl Genet. 1983 Jul;66(1):1-7. doi: 10.1007/BF00281838.
2
Homozygosity for Pc 1 Duarte-like protein in primates and other animals.灵长类动物和其他动物中Pc 1杜阿尔特样蛋白的纯合性。
Am J Hum Genet. 1981 Jan;33(1):134-7.
3
Two-dimensinal gel electrophoresis of rat liver nuclear washes, nuclear matrix, and hnRNA proteins.
大鼠肝细胞核洗液、核基质和核内不均一RNA蛋白的双向凝胶电泳。
J Cell Biol. 1980 Jul;86(1):135-55. doi: 10.1083/jcb.86.1.135.
4
Neurobiological approaches in human behavior genetics.人类行为遗传学中的神经生物学方法。
Behav Genet. 1981 Mar;11(2):87-102. doi: 10.1007/BF01065620.
5
Genetic analysis of human lymphocyte proteins by two-dimensional gel electrophoresis: 3. Frequent occurrence of genetic variants in some abundant polypeptides of PHA-stimulated peripheral blood lymphocytes.通过二维凝胶电泳对人淋巴细胞蛋白质进行遗传分析：3. 促有丝分裂原激活的外周血淋巴细胞某些丰富多肽中遗传变异的频繁出现。
Hum Genet. 1982;62(2):142-7. doi: 10.1007/BF00282303.
6
12-O-tetradecanoylphorbol 13-acetate-inducible proteins are synthesized at an increased rate in Bloom syndrome fibroblasts.12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯诱导蛋白在布卢姆综合征成纤维细胞中的合成速率增加。
Proc Natl Acad Sci U S A. 1982 Dec;79(24):7886-90. doi: 10.1073/pnas.79.24.7886.
7
Human lymphocyte polymorphisms detected by quantitative two-dimensional electrophoresis.通过定量二维电泳检测的人类淋巴细胞多态性。
Am J Hum Genet. 1983 Sep;35(5):827-37.
8
Neuroimmunology in multiple sclerosis.多发性硬化症中的神经免疫学
Ital J Neurol Sci. 1983 Jun;4(2):161-8. doi: 10.1007/BF02043899.
9
Twenty-seven protein polymorphisms by two-dimensional electrophoresis of serum, erythrocytes, and fibroblasts in two pedigrees.通过对两个家系的血清、红细胞和成纤维细胞进行二维电泳分析出27种蛋白质多态性。
Am J Hum Genet. 1985 Sep;37(5):898-911.
10
The equine protease inhibitory system (Pi): abnormal expressions of PiF, PiL, and PiS1.马蛋白酶抑制系统（Pi）：PiF、PiL和PiS1的异常表达
Biochem Genet. 1986 Aug;24(7-8):529-43. doi: 10.1007/BF00504333.