Branski D, Lebenthal E
J Clin Gastroenterol. 1979 Sep;1(3):237-40. doi: 10.1097/00004836-197909000-00009.
Hirschsprung's disease is one of the more common causes of childhood bowel obstruction. The disease can cause enterocolitis which, untreated, may result in considerable mortality. We describe our evaluation of two infants who suffered from intractable diarrhea of infancy secondary to Hirschsprung's disease. We found that mucosal damage to the small bowel and disaccharidase deficiency are among the most important mechanisms producing this complications. Therefore, management of enterocolitis including parenteral alimentation should proceed as soon as the complication is observed.
先天性巨结肠症是儿童肠梗阻较常见的病因之一。该疾病可引发小肠结肠炎，若不治疗，可能导致相当高的死亡率。我们描述了对两名因先天性巨结肠症继发婴儿期顽固性腹泻的婴儿的评估情况。我们发现，小肠黏膜损伤和双糖酶缺乏是引发这种并发症的最重要机制。因此，一旦观察到该并发症，包括肠外营养在内的小肠结肠炎治疗就应立即展开。
