高脂血症大鼠中阿司匹林预防血栓形成的作用
Thrombosis prevention by acetylsalicylic acid in hyperlipemic rats.
作者信息
Renaud S, Godu J
出版信息
Can Med Assoc J. 1970 Nov 7;103(10):1037-40.
Abstract
In rats, administration of acetylsalicylic acid (ASA) by stomach tube two hours before blood removal, or addition of the drug to platelet-rich plasma in vitro, markedly inhibited platelet aggregation induced by thrombin, ADP and collagen. Addition of ASA in vitro to human platelet-rich plasma also inhibited platelet aggregation by thrombin, ADP and collagen. In hyperlipemic rats, ASA (100 to 200 mg./kg.), administered by stomach tube once or five times, markedly inhibited the production of thrombosis initiated by intravenous injection of S. typhosa endotoxin. In these experiments, thrombosis prevention by ASA was associated with both a decrease in platelet aggregation and an increase in the recalcification plasma clotting time.
摘要
在大鼠中，在采血前两小时通过胃管给予乙酰水杨酸（ASA），或在体外将该药物添加到富含血小板的血浆中，可显著抑制凝血酶、ADP和胶原诱导的血小板聚集。在体外将ASA添加到富含人血小板的血浆中也可抑制凝血酶、ADP和胶原诱导的血小板聚集。在高脂血症大鼠中，通过胃管单次或五次给予ASA（100至200毫克/千克），可显著抑制静脉注射伤寒沙门氏菌内毒素引发的血栓形成。在这些实验中，ASA预防血栓形成与血小板聚集减少和复钙血浆凝血时间延长均有关。
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