用甾体避孕药处理的小鼠的细胞介导免疫反应。
Cell-mediated immune response in mice treated with steroidal contraceptives.
作者信息
Rangnekar K N, Rao S S, Joshi U M
出版信息
Clin Exp Immunol. 1975 Oct;22(1):183-9.
The splenomegaly assay (Simonsen, 1962) was standardized using different strains of rats and mice. Male Wistar rat (donor)-female Swiss mouse (host) was found to be the suitable combination that could be employed in subsequent experiments to study the potential of contraceptive steroids to alter CMIR. The index of splenomegaly appeared to increase in case of mice treated with combination oral contraceptives (Ovulen, Ovral or Enovid). The differences observed, however, neared significance only in the case of Ovral (0-05 less than P less than 0-1). Neither chlormadinone acetate nor megestrol acetate significantly altered the index of splenomegaly.
使用不同品系的大鼠和小鼠对脾肿大测定法（西蒙森，1962年）进行了标准化。发现雄性Wistar大鼠（供体）-雌性瑞士小鼠（宿主）是适合的组合，可用于后续实验，以研究避孕类固醇改变细胞介导免疫反应（CMIR）的潜力。在用复方口服避孕药（奥夫伦、奥维拉或炔诺酮）治疗的小鼠中，脾肿大指数似乎有所增加。然而，观察到的差异仅在奥维拉组接近显著水平（0.05＜P＜0.1）。醋酸氯地孕酮和醋酸甲地孕酮均未显著改变脾肿大指数。
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