大鼠体内烟酰素的代谢。烟酸代谢产物排泄的研究。
The metabolism of niacytin in the rat. Studies of the excretion of nicotinic acid metabolites.
作者信息
Mason J B, Kodicek E
出版信息
Biochem J. 1970 Dec;120(3):509-13. doi: 10.1042/bj1200509.
Abstract
- Nicotinic acid-deficient rats were given a dose of niacytin or an equivalent one of free nicotinic acid or hydrolysed niacytin. 2. The excretion of N'-methylnicotinamide and of tertiary nicotinoyl derivatives in urine showed that niacytin was not metabolized as free nicotinic acid, although hydrolysed niacytin was equivalent to free nicotinic acid. 3. Little or none of the niacytin dose was recovered as tertiary nicotinoyl derivatives in faeces. This result was not affected by fitting rats with tail-cups to prevent coprophagy. 4. At the high doses used niacytin restored the growth rate of the deficient animals because of a small degree of hydrolysis of the bound nicotinic acid.
摘要
- 给烟酸缺乏的大鼠一剂烟酰素或等量的游离烟酸或水解烟酰素。2. 尿液中N'-甲基烟酰胺和叔烟酰衍生物的排泄表明，烟酰素不像游离烟酸那样被代谢，尽管水解烟酰素等同于游离烟酸。3. 粪便中几乎没有或没有以叔烟酰衍生物的形式回收烟酰素剂量。给大鼠戴上尾杯以防止食粪症，这一结果不受影响。4. 在所用的高剂量下，由于结合烟酸的少量水解，烟酰素恢复了缺乏动物的生长速率。
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