Daly D M, Roeser R J, Moushegian G
Electroencephalogr Clin Neurophysiol. 1976 Feb;40(2):132-42. doi: 10.1016/0013-4694(76)90158-9.
Frequency-following responses (FFRs) evoked by 500 c/sec tone bursts 14 msec in duration, presented at 50 dB SL were recorded from Cz--A1 and Cz--A2 electrode derivations using eight subjects with normal bilateral hearing, and eight subjects with profound unilateral hearing loss. Monaural stimulation of either ear in normal subjects, and of the unimpaired ear in hearing-loss subjects, evoked larger responses from the ipsilateral electrode derivation than from the contralateral electrode derivation. Stimulation of the impaired ear in hearing-loss subjects evoked no response. Binaural stimulation in normal-hearing subjects evoked Cz--A1 and Cz--A2 responses of equal magnitude, each larger than either the ipsilateral or contralateral monaural response, but each slightly smaller than the sum of the ipsilateral and contralateral monaural responses. Binaural stimulation in hearing-loss subjects evoked responses equivalent to those obtained monaurally. The results provide evidence of binaural interaction in normal-hearing subjects and indicate that FFR arises from at least two separate symmetric neural sources, possibly by iterative activation of brainstem evoked response (BER) generators.
使用8名双侧听力正常的受试者和8名单侧重度听力损失的受试者，从Cz - A1和Cz - A2电极导联记录了由持续时间为14毫秒、频率为500赫兹、声强为50分贝感觉级的纯音脉冲诱发的频率跟随反应（FFR）。在正常受试者中，单耳刺激任一耳朵，以及在听力损失受试者中刺激未受损的耳朵，同侧电极导联诱发的反应大于对侧电极导联。在听力损失受试者中，刺激受损耳朵未诱发反应。在听力正常的受试者中，双耳刺激诱发的Cz - A1和Cz - A2反应幅度相等，每个反应均大于同侧或对侧单耳反应，但每个反应略小于同侧和对侧单耳反应之和。在听力损失受试者中，双耳刺激诱发的反应与单耳刺激获得的反应相当。结果为听力正常受试者的双耳相互作用提供了证据，并表明FFR至少源自两个独立的对称神经源，可能是通过脑干诱发反应（BER）发生器的迭代激活。
