Russo R, Bortolotti U, Fiore D, Lafisca N, Segafredo G, Fasoli G
G Ital Cardiol. 1979;9(11):1231-5.
A phonomecanocardiographic study in 33 patients who had undergone aortic valve replacement with a glutaraldehyde-preserved Hancock bioprosthesis, has been carried out 6 to 42 months after surgery. All xenografts were considered well functioning on the basis of clinical, electrocardiographic and radiographic evaluation. Typical phonocardiographic features of a well functioning porcine heterograft in aortic position were considered 1) an opening snap of variable intensity recorded in about 50% of the patients; 2) a normal closing sound; 3) a protosystolic ejection murmur which was always present and whose intensity was inversely related to the prosthesis size; and 4) the absence of a diastolic murmur. The anatomical and functional characteristics of the aortic valve of the pig are suggested to explain both the absence of a diastolic murmur and the pattern of the closing sound, which is undistinguishable from that of a normal aortic valve. Moreover, the reduced pliability of the right coronary cusp of the porcine valve, due to the muscular shelf at its base, with consequent limitation of the effective prosthetic orifice and relative stenosis of the device correlates well with both the opening snap and the sytolic ejection murmur.
对33例接受戊二醛保存的汉考克生物瓣膜主动脉瓣置换术的患者进行了心音心动图研究，研究在术后6至42个月进行。根据临床、心电图和影像学评估，所有异种移植物均被认为功能良好。主动脉位置功能良好的猪异种移植物典型的心音图特征被认为有：1）约50%的患者记录到强度可变的开瓣音；2）正常的关闭音；3）始终存在的收缩期喷射性杂音，其强度与人工瓣膜大小呈负相关；4）无舒张期杂音。猪主动脉瓣的解剖和功能特征被认为可以解释舒张期杂音的缺失以及关闭音的模式，后者与正常主动脉瓣的关闭音无法区分。此外，猪瓣膜右冠状动脉瓣叶由于其基部的肌肉架而柔韧性降低，从而导致有效人工瓣膜口受限和装置相对狭窄，这与开瓣音和收缩期喷射性杂音均密切相关。
