Kellerhals B, de Uthemann B
Int J Pediatr Otorhinolaryngol. 1979 Jul;1(1):79-85. doi: 10.1016/0165-5876(79)90031-4.
Usually, nasal polyposis in early childhood (children aged less than 5 years) is caused by cystic fibrosis of Kartagener's syndrome. In later age groups, recurrent sinus infections, allergy and ASA disease (asthma, aspirin intolerance and nasal polyps) have to be taken into consideration. Four cases of early childhood polyposis are reported which fit into none of these etiological groups. This newly defined Woakes' syndrome comprises recurrent nasal polyposis with broadening of the nose, frontal sinus aplasia, bronchiectasis, and dyscrinia (production of highly viscous mucus). The disease seems to be hereditary. The possible origins of the disease are discussed.
通常，幼儿期（5岁以下儿童）鼻息肉病由卡塔格内综合征的囊性纤维化引起。在年龄较大的人群中，必须考虑复发性鼻窦感染、过敏和阿司匹林三联征（哮喘、阿司匹林不耐受和鼻息肉）。本文报告了4例幼儿期息肉病病例，这些病例均不符合上述任何病因分类。这种新定义的沃克斯综合征包括复发性鼻息肉伴鼻增宽、额窦发育不全、支气管扩张和分泌异常（产生高粘性黏液）。该疾病似乎具有遗传性。文中讨论了该疾病可能的起源。
