Wémeau J L, Lefebvre J, Linquette M
Nouv Presse Med. 1979 Feb 3;8(6):415-9.
As first described in serious systemic illnesses isolated decreased T3 plasma concentration was related to impaired peripheral conversion of T4, to T3 with preferential production of reverse T3 (rT3). A "low T3 syndrome" was seen in 47 out of 109 patients with extra-thyroidal diseases. Metabolic state, TSH and TSH responses to TRH were normal despite of low T3 concentration. Euthyroidism seems mainly due to T4 itself in these patients.
正如首次在严重全身性疾病中所描述的那样，孤立的血浆T3浓度降低与T4向T3的外周转化受损以及反向T3（rT3）的优先产生有关。109例甲状腺外疾病患者中有47例出现“低T3综合征”。尽管T3浓度较低，但代谢状态、促甲状腺激素（TSH）以及TSH对促甲状腺激素释放激素（TRH）的反应均正常。在这些患者中，甲状腺功能正常似乎主要归因于T4本身。
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