正常人和糖尿病患者血浆中垂体来源的胰岛素拮抗剂。
Insulin antagonist of pituitary origin in plasma of normal and diabetic subjects.
作者信息
Zimmet P, Ng F M, Bornstein J, Armstrong J M, Taft H P
出版信息
Br Med J. 1971 Jan 23;1(5742):203-4. doi: 10.1136/bmj.1.5742.203.
Abstract
Studies on ultrafiltrates of the plasma of normal and diabetic subjects have shown that a polypeptide of similar characteristics to the growth-hormone-derived polypeptide In-G is present in higher concentrations in diabetic subjects, thus indicating a possible role in the pathogenesis of diabetes mellitus. The polypeptide is absent from the plasma of hypophysectomized diabetic patients.
摘要
对正常人和糖尿病患者血浆超滤液的研究表明，一种与生长激素衍生多肽In-G具有相似特征的多肽在糖尿病患者体内的浓度更高，因此表明其在糖尿病发病机制中可能发挥作用。垂体切除的糖尿病患者血浆中不存在这种多肽。
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本文引用的文献
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Potentiation of insulin action in normal subjects by a pituitary polypeptide.一种垂体多肽对正常受试者胰岛素作用的增强作用。
Br Med J. 1969 Aug 23;3(5668):451-2. doi: 10.1136/bmj.3.5668.451.
2
Pituitary polypeptide with hypoglycaemic action in diabetes mellitus.对糖尿病有降血糖作用的垂体多肽。
Br Med J. 1969 Apr 19;2(5650):157-8. doi: 10.1136/bmj.2.5650.157.
3
The effect of a growth hormone fraction on the activities of glyceraldehyde-3-phosphate dehydrogenase.一种生长激素组分对3-磷酸甘油醛脱氢酶活性的影响。
Biochim Biophys Acta. 1968 Feb 1;156(1):38-43. doi: 10.1016/0304-4165(68)90101-3.
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Mechanism of the diabetogenic action of growth hormone. II. Effect of polypeptides derived from growth hormone on fat metabolism.生长激素致糖尿病作用的机制。II. 源自生长激素的多肽对脂肪代谢的影响。
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Mechanism of the diabetogenic action of growth hormone. I. Effect of polypeptides derived from growth hormone on glycolysis in muscle.生长激素致糖尿病作用的机制。I. 生长激素衍生多肽对肌肉糖酵解的影响。
Biochim Biophys Acta. 1969 Nov 18;192(2):265-70. doi: 10.1016/0304-4165(69)90364-x.
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