对糖尿病有降血糖作用的垂体多肽。
Pituitary polypeptide with hypoglycaemic action in diabetes mellitus.
作者信息
Armstrong J M, Bornstein J, Ng F M, Taft H P
出版信息
Br Med J. 1969 Apr 19;2(5650):157-8. doi: 10.1136/bmj.2.5650.157.
Abstract
A polypeptide isolated by the hydrolysis of growth hormone, studied in five patients with diabetes mellitus, has been shown able to produce hypoglycaemia, presumably by modifying the anti-insulin action of pituitary growth hormone. Possibly this substance may be suitable for treating cases of insulin resistance or when a circulating inhibitor of glucose uptake is present.
摘要
一种通过水解生长激素分离出的多肽，在5名糖尿病患者身上进行了研究，结果显示它能够产生低血糖，推测是通过改变垂体生长激素的抗胰岛素作用来实现的。这种物质可能适用于治疗胰岛素抵抗的病例，或者存在循环性葡萄糖摄取抑制剂的情况。
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引用本文的文献
1
Potentiation of insulin action in normal subjects by a pituitary polypeptide.一种垂体多肽对正常受试者胰岛素作用的增强作用。
Br Med J. 1969 Aug 23;3(5668):451-2. doi: 10.1136/bmj.3.5668.451.
2
Insulin antagonist of pituitary origin in plasma of normal and diabetic subjects.正常人和糖尿病患者血浆中垂体来源的胰岛素拮抗剂。
Br Med J. 1971 Jan 23;1(5742):203-4. doi: 10.1136/bmj.1.5742.203.
3
Growth hormone and diabetes.生长激素与糖尿病。
Br Med J. 1971 Jan 23;1(5742):186.
4
[Metabolic actions of the somatropic hormone].[生长激素的代谢作用]
Acta Diabetol Lat. 1971 May-Jun;8(3):538-51. doi: 10.1007/BF01550886.
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Diabetes. 1959 Mar-Apr;8(2):92-3. doi: 10.2337/diab.8.2.92.
2
The effect of a growth hormone fraction on the activities of glyceraldehyde-3-phosphate dehydrogenase.一种生长激素组分对3-磷酸甘油醛脱氢酶活性的影响。
Biochim Biophys Acta. 1968 Feb 1;156(1):38-43. doi: 10.1016/0304-4165(68)90101-3.
3
Pituitary peptides with direct action on the metabolism of carbohydates and fatty acids.对碳水化合物和脂肪酸代谢有直接作用的垂体肽。
Biochim Biophys Acta. 1968 Feb 1;156(1):31-7. doi: 10.1016/0304-4165(68)90100-1.
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