Braun J M, Gongora G, Gongora R, Roy M, Bedu M, Castillon du Perron M, Jammet H, Drutel P
Poumon Coeur. 1979;35(6):355-60.
The result of a study done on 52 subjects including a thorough ventilatory functional test and the radioisotopic measurement of inhaled particles deposition, by working out the TB/P ratio, revealed that: 1. giving aerosol needs an exacting technique when used for quantitative aims; 2. ratio TB/P is increased in patients with chronic broncho-pulmonary diseases, because of a predominantly tracheo-bronchial deposition of particles; 3. in patients with a satisfactory ventilatory function the TB/P ratio is increased; on the other hand in patients with ventilatory disorders, the ratio is normal. The repartition of particles deposition between the compartments TB and B depends therefore not only on factors involving ventilatory functional values but also on the physiopathological factors not included in them.
一项针对52名受试者开展的研究结果,包括进行全面的通气功能测试以及对吸入颗粒沉积进行放射性同位素测量,并通过计算TB/P比值,结果显示:1. 当用于定量目的时,雾化给药需要精确的技术;2. 慢性支气管肺部疾病患者的TB/P比值升高,原因是颗粒主要沉积在气管支气管;3. 通气功能良好的患者TB/P比值升高;另一方面,通气功能障碍患者的该比值正常。因此,颗粒在TB和B区室之间的沉积分配不仅取决于涉及通气功能值的因素,还取决于其中未包含的生理病理因素。