体内白血病细胞群体的参数化
Parameterization of in vivo leukemic cell populations.
作者信息
Rubinow S I, Lebowitz J L, Sapse A M
出版信息
Biophys J. 1971 Feb;11(2):175-88. doi: 10.1016/S0006-3495(71)86206-9.
A quantitative mathematical formalism which was previously introduced has been utilized to obtain the cell kinetic parameters which characterize the in vivo leukemic myeloblast cell populations in two patients studied by Clarkson and his coworkers. The principal tentative conclusions are: (a) all cells which are actively proliferating must enter the resting state following cell division; (b) about 90% of the cells are in the resting state; (c) the generation time of the cells in the active state is about 25 hr and is essentially the same as the generation time of normal myeloblast cells.
一种先前引入的定量数学形式体系已被用于获取细胞动力学参数，这些参数表征了Clarkson及其同事研究的两名患者体内白血病成髓细胞群体的特征。主要初步结论如下：(a) 所有活跃增殖的细胞在细胞分裂后必须进入静止状态；(b) 约90%的细胞处于静止状态；(c) 活跃状态下细胞的增殖周期约为25小时，与正常成髓细胞的增殖周期基本相同。
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