甲状旁腺激素对家鼩（Suncus murinus）中C细胞、甲状旁腺、血清钙和血清磷水平的影响。
Influence of parathormone on C cells, parathyroid glands, serum calcium and serum phosphate levels in the house shrew, Suncus murinus.
作者信息
Srivastav A K, Swarup K
出版信息
Arch Anat Microsc Morphol Exp. 1979;68(4):227-35.
A chronic hypercalcaemia was induced in Suncus murinus by the daily subcutaneous injections of parathormone for 15 days. Serum calcium increased 4 hours after the first injection (+ 0.88 mg/100 ml), it reached its highest value on day 10 (+ 2.18 mg/100 ml), and then decreased slightly at the end of the experiment (day 15). The serum phosphate level in treated animals showed a progressive fall throughout the experiment. Serial sections of thyroid-parathyroid complex were subjected to selective staining for C cells identification. The chronic hypercalcaemia increased the number of C cells. This was supported by the presence of mitotic figures. Degranulation of the secretory material was observed as the result of the chronic hypercalcaemia; degenerative changes were found in some C cells. The chronic hypercalcaemia also inhibited the activity of parathyroid "Chief-Cells" which ultimately degenerated.
通过每天皮下注射甲状旁腺激素，连续15天在臭鼩身上诱发慢性高钙血症。首次注射后4小时血清钙升高（+0.88mg/100ml），在第10天达到最高值（+2.18mg/100ml），然后在实验结束时（第15天）略有下降。在整个实验过程中，接受治疗的动物血清磷酸盐水平呈逐渐下降趋势。对甲状腺-甲状旁腺复合体的连续切片进行选择性染色以识别C细胞。慢性高钙血症增加了C细胞的数量。有丝分裂图的存在支持了这一点。观察到慢性高钙血症导致分泌物质脱颗粒；在一些C细胞中发现了退行性变化。慢性高钙血症还抑制了甲状旁腺“主细胞 ”的活性，这些细胞最终发生了退化。
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