[不同剂量的L-氨基酸铜配合物对大鼠胃酸分泌的影响]

[Effects of graded doses of copper complexes with L-aminoacids on gastric acid secretion in the rat].

作者信息

Marletta F, Rizzarelli E, Mangiameli A, Brogna A, Sammartano S, Monaco S, Blasi A

出版信息

Boll Soc Ital Biol Sper. 1979 Apr 30;55(8):769-75.

Abstract

Gastric acid responses to intragastric administration of graded doses (14-30-45 mg/Kg) of copper (II) complexes with aminoacids (two simple complexes, Cu-Trp2 and Cu-Phe2, and on mixed complex, Cu-Trp-Phe) were investigated in Shay rats. The results (% inhibition of H+ mEq/4h) shown that graded doses of copper complexes caused a progressive inhibition on gastric acid secretion, and that percentage inhibition values were, for all complexes, in linear correlation with employed doses. A possible mechanism by which copper complexes affect gastric acid secretion is discussed.

摘要

在沙伊大鼠中研究了胃内给予不同剂量（14 - 30 - 45毫克/千克）的氨基酸铜（II）配合物（两种简单配合物，Cu-Trp2和Cu-Phe2，以及一种混合配合物，Cu-Trp-Phe）后胃酸的反应。结果（H⁺毫当量/4小时的抑制百分比）表明，不同剂量的铜配合物对胃酸分泌产生了逐渐增强的抑制作用，并且对于所有配合物而言，抑制百分比值与所用剂量呈线性相关。文中讨论了铜配合物影响胃酸分泌的一种可能机制。