Nelson R P, Traisman H S, Deddish R B, Green O C
Diabetes Care. 1978 Jan-Feb;1(1):37-9. doi: 10.2337/diacare.1.1.37.
Schmidt's syndrome (thyroid and adrenal insufficiency) and concurrent diabetes mellitus represent an intriguing multiple endocrinopathy in children. This report describes an eleven-year-old girl with diabetes of eight years' duration presenting in adrenal crisis. Serum thyroxine was undetectable, and antibodies to both thyroglobulin and adrenal tissue were found in high titer. The child's condition stabilized with hormonal replacement therapy, except for persistent growth failure. Approximately two years later she succumbed during a rapidly fulminant episode of ketoacidosis. The natural history of her illness supports recent speculation based on serologic data that juvenile diabetes mellitus may be an immunologic disorder in some children.
施密特综合征（甲状腺和肾上腺功能不全）并发糖尿病是儿童中一种引人关注的多发性内分泌病。本报告描述了一名患糖尿病8年的11岁女孩，出现肾上腺危象。血清甲状腺素检测不到，且发现抗甲状腺球蛋白和肾上腺组织的抗体效价很高。经激素替代治疗后，患儿病情稳定，但仍持续生长发育迟缓。大约两年后，她在一次快速爆发的酮症酸中毒发作中死亡。她疾病的自然病程支持了最近基于血清学数据的推测，即青少年糖尿病在某些儿童中可能是一种免疫性疾病。
