Grieco C, Silipo C, Vittoria A
Farmaco Sci. 1979 May;34(5):433-64.
Correlation analysis assumes that the physicochemical factors governing the transport, metabolism and drug-receptor interaction can be factored into hydrophobic-lipophilic component, polarizability and dispersion forces, electronic and steric effects and into indeterminate factors. Using computerized regression analysis, a generalized equation can be formulated to correlate the biological response of a set of compounds with their chemical structures in terms of physicochemical parameters of substituents. In order to explore the scope of each defined physicochemical parameter, correlations between biological effects and some combination of substituent indices are discussed.
相关性分析假定，支配转运、代谢及药物 - 受体相互作用的物理化学因素可分解为疏水 - 亲脂成分、极化率和色散力、电子和空间效应以及不确定因素。通过计算机化回归分析，可以制定一个广义方程，根据取代基的物理化学参数将一组化合物的生物学反应与其化学结构相关联。为了探究每个定义的物理化学参数的范围，将讨论生物学效应与取代基指数的某些组合之间的相关性。
