噬菌体ε34对沙门氏菌O抗原的转化机制
Mechanism of conversion of the salmonella O antigen by bacteriophageepsilon 34.
作者信息
Wright A
出版信息
J Bacteriol. 1971 Mar;105(3):927-36. doi: 10.1128/jb.105.3.927-936.1971.
Abstract
The structural determinants for antigen 34 in the E group salmonella are glucosyl substituents on the galactosyl units of the O antigen which has a mannosylrhamnosylgalactose repeating sequence. The temperate bacteriophage epsilon(34) brings about the production of antigen 34. It has been shown here that glucose is transferred from uridine diphosphate glucose to the O antigen via a glucosyl-lipid intermediate in a two-step reaction. Glucose is linked through carbon 1 to the lipid by a phosphodiester bridge, the glucosyl bond having the beta-anomeric configuration. The lipid is a C(55)-polyisoprenoid alcohol, each isoprene unit having one double bond. It is the same lipid which is involved in the synthesis of the O antigen repeating sequence.
摘要
E 组沙门氏菌中抗原 34 的结构决定因素是 O 抗原半乳糖基单元上的葡萄糖基取代基，该 O 抗原具有甘露糖基鼠李糖基半乳糖重复序列。温和噬菌体ε(34) 可促使抗原 34 的产生。本文已表明，葡萄糖通过两步反应经葡萄糖基脂质中间体从尿苷二磷酸葡萄糖转移至 O 抗原。葡萄糖通过碳 1 经磷酸二酯桥与脂质相连，葡萄糖苷键具有β-异头构型。该脂质是一种 C(55) - 聚异戊二烯醇，每个异戊二烯单元有一个双键。它与 O 抗原重复序列的合成所涉及的脂质相同。
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