Hofer J F, Schwarzmeier J D, Marosi L, Paietta E, Radaskiewicz T
Acta Med Austriaca. 1979;6(5):222-5.
In its conventional meaning, chronic lymphatic leukemia (CLL) describes a variety of clinical and prognostical aspects. Since it was found using immunohistological methods that a remarkable number of lymphoplasmacytoid lymphoma (immunocytoma) were initially considered to belong to the CLL-group according to cell morphology, cell count and clinical status, the purpose of this study was to set up clinical and laboratory parameters separating CLL and immunocytoma. This was accomplished by categorizing 71 patients of preliminary CLL by age, sex, distribution of B and T lymphocytes, cell morphology, symptoms at the time of diagnosis, clinical course, electrophoresis and quantitative immunoglobulines. According to these features, the sample of patients was divided into three groups: Group 1: chronic lymphatic leukemia probable. Group 2: immunocytoma probable. Group 3: clear-cut separation is not possible. In these patients a lymphnode extirpation and a fluorescent examination of surface immunoglobulines should be performed.
按照其传统定义，慢性淋巴细胞白血病（CLL）涵盖了多种临床和预后方面的情况。由于运用免疫组织学方法发现，相当数量的淋巴浆细胞样淋巴瘤（免疫细胞瘤）最初根据细胞形态、细胞计数和临床状况被认为属于CLL组，本研究的目的是确立区分CLL和免疫细胞瘤的临床及实验室参数。通过对71例初步诊断为CLL的患者按年龄、性别、B和T淋巴细胞分布、细胞形态、诊断时的症状、临床病程、电泳及定量免疫球蛋白进行分类来实现这一目的。根据这些特征，将患者样本分为三组：第1组：可能为慢性淋巴细胞白血病。第2组：可能为免疫细胞瘤。第3组：无法明确区分。对于这些患者，应进行淋巴结切除及表面免疫球蛋白的荧光检查。
