Shapiro R F, Wiesner K B, Bryan B L, Utsinger P D, Resnick D, Castles J J
Lancet. 1976 Jan 31;1(7953):230-1. doi: 10.1016/s0140-6736(76)91344-1.
Of the many associations between histocompatibility antigens and human diseases a prominent one is that between HLA-B27 and inflammatory arthropathies. Hypotheses to explain this association include the B27 gene being linked to a specific immune-response gene required for disease expression and the B27 antigen acting via molecular mimicry with a microorganism or as a microorganism receptor. Alternatively, the HLA-B27 gene might be closely related to a gene which influences bone formation. The finding of a significant association between B27 and Forestier's disease, a disease characterised by abundant new bone formation, supports such a hypothesis.
在组织相容性抗原与人类疾病的众多关联中，一个显著的关联是HLA - B27与炎性关节病之间的关联。解释这种关联的假说是，B27基因与疾病表达所需的特定免疫反应基因相关联，并且B27抗原通过与微生物的分子模拟作用或作为微生物受体发挥作用。另外，HLA - B27基因可能与影响骨形成的基因密切相关。B27与福里斯特尔病（一种以大量新骨形成为特征的疾病）之间存在显著关联这一发现支持了这一假说。
