Triplett D A
Ther Drug Monit. 1979;1(2):173-97.
Heparin has been used extensively in the treatment of venous thrombosis and pulmonary embolus and more recently as a prophylactic measure in high-risk patient populations. The chemistry and biologic, pharmacologic, and physiologic actions of heparin are discussed, with some emphasis on the role of antithrombin III. The various modes of heparin administration, dosage regimens, requirements, and indications for therapy are reviewed. Full-dose and minidose heparin therapy are discussed in detail. The advantages and disadvantages of the various laboratory tests used to monitor heparin therapy are covered, along with standardization of heparin preparations. Finally, complications associated with heparin therapy are pointed out.
肝素已广泛应用于静脉血栓形成和肺栓塞的治疗，最近也作为高危患者群体的预防措施。本文讨论了肝素的化学性质、生物学、药理学和生理学作用，重点阐述了抗凝血酶III的作用。回顾了肝素的各种给药方式、剂量方案、治疗要求和适应症。详细讨论了全剂量和小剂量肝素治疗。涵盖了用于监测肝素治疗的各种实验室检查的优缺点，以及肝素制剂的标准化。最后，指出了与肝素治疗相关的并发症。
