Dhurandhar R W, Teasdale S J, Mahon W A
Can Med Assoc J. 1971 Jul 24;105(2):161-5 passim.
Nine patients who had recurrent ventricular fibrillation following acute myocardial infarction or angina were given bretylium tosylate in a dose of 5 mg./kg. intramuscularly every eight hours after other measures had proved ineffective. Provided the patients were not in shock or in heart failure, there was a considerable reduction in the episodes of ventricular fibrillation.A second group of nine patients who developed recurrent ventricular fibrillation following open heart surgery were given bretylium intravenously, which controlled the arrhythmia in every instance.Bretylium did not completely abolish ventricular premature beats but the latter did not initiate ventricular fibrillation even when they occurred on the T wave.
9例急性心肌梗死或心绞痛后发生反复心室颤动的患者，在其他措施均无效后，每8小时给予5mg/kg的甲苯磺酸溴苄铵肌肉注射。只要患者没有休克或心力衰竭，心室颤动的发作次数就会显著减少。第二组9例心脏直视手术后发生反复心室颤动的患者接受了静脉注射甲苯磺酸溴苄铵，均控制了心律失常。溴苄铵并没有完全消除室性早搏，但即使室性早搏出现在T波上，也不会引发心室颤动。
