Saxena V
Biochem Exp Biol. 1979;15(2):133-8.
O-isopropoxyphenylmethyl carbamate in S. fossilis chromosomes has been found to induce fragmentation at pachytene and diakinesis. Fragmentation frequency increased with the increase in dose. The yield of total clumping at different doses and different intervals was inconsistent. Precocious despiralization and stickiness were also observed. Time interval was observed to be a factor in the appearance of anomalies with different doses. The dicentric bridges which were frequent at low dose, diminished in quantum with the increase in dose.
已发现化石链霉菌染色体中的邻异丙氧基苯基甲基氨基甲酸酯在粗线期和终变期诱导断裂。断裂频率随剂量增加而增加。不同剂量和不同时间间隔下的总结块产量不一致。还观察到早熟解螺旋和粘连现象。观察到时间间隔是不同剂量下异常出现的一个因素。低剂量时常见的双着丝粒桥随着剂量增加而数量减少。