Tavassoli M
Blood Cells. 1979 Mar 23;5(1):89-99.
Freeze-fracture and thin-section electron microscopy indicate that a sequence of fusion-fission leads to reorganization of membranes and the demarcation of platelets within the cytoplasm of megakaryocyte. Invagination of the megakaryocyte plasma membrane leads to the formation of tubular structures within the cytoplasm of megakaryocytes. Fusion of these tubular membranes in the plane of their long axes is followed by fission in the perpendicular plane. This results in the formation of two flat membranes, forming plasma membranes of two adjacent platelets. A similar fusion-fission reorganization of membranes could mediate a wide variety of other biologic phenomena. These observations also indicate that megakaryocytes are located in the subendothelial compartment of the marrow with their projections penetrating the endothelium and reaching the lumen. This direct contact with the circulation may serve as a means of receiving information as to the requirements of the body for platelet production.
冷冻断裂和超薄切片电子显微镜检查表明，一系列融合-裂变导致膜的重组以及巨核细胞胞质内血小板的划分。巨核细胞质膜的内陷导致巨核细胞胞质内形成管状结构。这些管状膜在其长轴平面上融合，随后在垂直平面上裂变。这导致形成两个扁平膜，形成两个相邻血小板的质膜。类似的膜融合-裂变重组可能介导多种其他生物学现象。这些观察结果还表明，巨核细胞位于骨髓的内皮下隔室，其突起穿透内皮并到达管腔。与循环系统的这种直接接触可能是接收有关身体对血小板生成需求信息的一种方式。
