Arnaud J P, Simon P, Ollier J C, Koehl C, Adloff M
J Chir (Paris). 1979 Nov;116(11):633-6.
An attempt is made to define the usefulness and limitations of carcinoembryonic antigen (CEA) radioimmunoassay for evaluation of diagnosis, tumor resection and detection of tumor relapse in 108 patients with colorectal carcinoma. Preoperative CEA levels were correlated with pathological stage and tumors localisations. Increasing levels of CEA were found with advanced stage of disease (Stage C and D lesions). Our results indicate: 1) that an incomplete drop in circulating CEA level one month after surgery was a bad prognostic sign; 2) that relapses of colon and rectum carcinoma can be detected by increased CEA levels months before the appearance of any clinical evidence.
本研究旨在确定癌胚抗原(CEA)放射免疫测定在108例结直肠癌患者的诊断评估、肿瘤切除及肿瘤复发检测中的实用性和局限性。术前CEA水平与病理分期及肿瘤定位相关。随着疾病进展(C期和D期病变),CEA水平升高。我们的结果表明:1)术后1个月循环CEA水平未完全下降是不良预后指标;2)在出现任何临床证据数月前,CEA水平升高可检测出结肠癌和直肠癌复发。