Dauplat J, Gauthier J P, Fonck Y, Bruhat M, Giraud B
J Chir (Paris). 1979 Nov;116(11):651-7.
Two benign liver tumours are described in women who had taken oral contraceptives. These were cases of focal nodular hyperplasia and a liver cell adenoma. These lesions are benign, and were discovered on routine examination as they were not responsible for any clinical sign, as is usual except in cases of peritoneal rupture, where the patient presents with a dramatic hemoperitoneum. Oral contraceptive were found to be associated as in many recent cases. Oestro-progestins were found to be responsible for an increase in hepatic metabolism, which gave rise to biochemical, histological and sometimes clinical changes in the form of jaundice or a tumour. There is no proof of this mechanism but the supervision of women on contraceptives should include a search for a hepatic tumour for which surgical treatment is necessary to prevent complications.
本文描述了两名服用口服避孕药的女性体内出现的两种良性肝脏肿瘤。它们分别是局灶性结节性增生和肝细胞腺瘤。这些病变是良性的,在常规检查中被发现,因为它们通常不会引发任何临床症状,除非发生腹膜破裂,此时患者会出现严重的腹腔内出血。正如最近许多病例所显示的那样,口服避孕药被发现与此有关。发现雌孕激素会导致肝脏代谢增加,进而引发黄疸或肿瘤等生化、组织学变化,有时还会出现临床症状。虽然尚无证据证明这一机制,但对服用避孕药的女性进行监测时应包括对肝脏肿瘤的筛查,必要时需进行手术治疗以预防并发症。