Blumgart L H, Leach K G, McLachlan M S, Seager S, Ryan C J
Gut. 1971 Jul;12(7):585-91. doi: 10.1136/gut.12.7.585.
A technique for subcutaneous transposition of the spleen in the rat is described. The preparation has been developed as a reliable means of transplenic portal injection. It has been shown that different substances injected into the pulp of the transposed spleen are cleared and not pooled in the organ. The development of porta-systemic venous communications has been demonstrated and their detection radiologically and by isotope techniques is illustrated. It is suggested that the technique outlined in this communication may be of value in the study of the portal circulation, the function of the liver, and in the investigation of drug action.If adequate porta-systemic venous connexions are present the portal vein can be tied above its splenic tributary and the animal will survive. The method offers a simple means of porta-systemic diversion in the rat.
本文描述了一种大鼠脾脏皮下移位的技术。该制备方法已发展成为一种可靠的经脾门静脉注射手段。研究表明，注入移位脾脏髓质的不同物质会被清除，不会在器官中蓄积。已证实门体静脉交通支的形成，并通过放射学和同位素技术展示了其检测方法。建议本文所述技术可能在门静脉循环研究、肝脏功能研究以及药物作用研究中具有价值。如果存在足够的门体静脉连接，可在脾静脉分支上方结扎门静脉，动物仍可存活。该方法为大鼠提供了一种简单的门体分流手段。
