环丙烷和乙醚对下丘脑后外侧某些单位的兴奋作用。
Excitation of certain posterolateral hypothalamic units by cyclopropane and ether.
作者信息
Millar R A, Silver I A
出版信息
Br J Pharmacol. 1971 Jul;42(3):315-27. doi: 10.1111/j.1476-5381.1971.tb07116.x.
Abstract
- Extracellular activity was recorded from single units in the posterolateral hypothalamus in nineteen cats before, during, and after the administration of the inhalation anaesthetics cyclopropane, diethyl ether and halothane.2. Unit discharge was significantly increased by 25-50% cyclopropane in eighteen of the forty-four cells tested with this anaesthetic, and in seven of fourteen cells tested with diethyl ether. This excitatory effect was associated with cortical EEG suppression.3. The remaining cells tested were depressed by cyclopropane or ether, and this also occurred during halothane administration.4. Excitation of certain cells in the posterolateral hypothalamus is discussed in relation to the increased preganglionic sympathetic activity evoked by cyclopropane and ether.
摘要
在19只猫吸入环丙烷、乙醚和氟烷等麻醉剂之前、期间和之后，记录了下丘脑后外侧单个神经元的细胞外活动。
在使用环丙烷测试的44个细胞中，有18个细胞的单位放电率显著增加了25% - 50%；在使用乙醚测试的14个细胞中，有7个细胞出现这种情况。这种兴奋作用与皮层脑电图抑制有关。
其余测试的细胞被环丙烷或乙醚抑制，在使用氟烷时也出现这种情况。
讨论了下丘脑后外侧某些细胞的兴奋与环丙烷和乙醚引起的节前交感神经活动增加之间的关系。
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2
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Am J Physiol. 1960 Feb;198:366-70. doi: 10.1152/ajplegacy.1960.198.2.366.
3
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Physiol Rev Suppl. 1960 Apr;4:116-35.
4
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5
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7
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