Cohen M M
Can Med Assoc J. 1971 Aug 7;105(3):263-9 passim.
All proved cases of perforated peptic ulcer occurring in the Greater Vancouver area during the decade 1959-1968 have been studied. The incidence of perforation was approximately 10 per 100,000 population. The mean age was 55 years and the peak age incidence was in the fifth decade. The site of perforation was pyloroduodenal in 88% of cases and simple closure was the treatment employed in 81%. The overall mortality rate was 18.3% and one-third of these fatalities were due to misdiagnosis. The operative mortality rate was 9%.The overall mortality rate was significantly greater among women and the elderly, in gastric perforations, and in perforations occurring between 11 p.m. and 8 a.m.A close correlation was found between operative mortality rate and the time interval between perforation and operation. This elapsed time was found to be significantly greater among women and the elderly, in gastric perforations and in perforations occurring during the night.
对1959年至1968年十年间大温哥华地区所有已证实的消化性溃疡穿孔病例进行了研究。穿孔发生率约为每10万人中10例。平均年龄为55岁，发病高峰年龄在第五个十年。88%的病例穿孔部位在幽门十二指肠，81%的病例采用单纯缝合治疗。总死亡率为18.3%，其中三分之一的死亡是由于误诊。手术死亡率为9%。女性、老年人、胃穿孔患者以及晚上11点至早上8点发生的穿孔患者的总死亡率显著更高。手术死亡率与穿孔至手术的时间间隔密切相关。发现女性、老年人、胃穿孔患者以及夜间发生的穿孔患者的这段时间明显更长。
