Dausset J, Gluckman E, Lemarchand F, Nunez-Roldan A, Contu L, Hors J
Nouv Rev Fr Hematol Blood Cells. 1977;18(2):315-24.
In 68 idiopathic aplastic anemia patients (65 HLA genotypes), HLA-A2 is slightly increased (p corrected less than 0.03) leading to a relative risk of 2.30. A slight excess of homozygotes for HLA-A was observed (22.2 vs. 14.09%), involving mostly the A2 antigen. In the siblings the patients were more frequently homozygote A2 than by chance (p less than 0.005). The same trends are observed in Fanconi's anemia = out of 18 patients, 7 are HLA-A homozygote (of whom 4 are A2). The hypothesis of the existence of one or several recessive genes involved in hematopoiesis situated close to HLA-A is advanced.
在68例特发性再生障碍性贫血患者（65种HLA基因型）中，HLA - A2略有增加（校正后p值小于0.03），相对风险为2.30。观察到HLA - A纯合子略有过量（22.2%对14.09%），主要涉及A2抗原。在同胞中，患者为A2纯合子的频率高于预期偶然发生率（p值小于0.005）。在范科尼贫血中也观察到相同趋势 = 在18例患者中，7例为HLA - A纯合子（其中4例为A2）。提出了存在一个或几个与造血相关的隐性基因且位于靠近HLA - A位置的假说。
