异丙肾上腺素、奥西那林和沙丁胺醇气雾剂对哮喘患者的支气管扩张及心脏效应
Bronchodilator and cardiac effects of isoprenaline, orciprenaline, and salbutamol aerosols in asthma.
作者信息
Milner A D, Ingram D
出版信息
Arch Dis Child. 1971 Aug;46(248):502-7. doi: 10.1136/adc.46.248.502.
Abstract
The bronchodilator and cardiac effects of 0·5% isoprenaline, 2·5% orciprenaline, and 0·5% salbutamol, and a placebo solution inhaled as a nebulized mist from a Wright nebulizer were compared with the help of 12 asthmatic children. All three active drugs produced similar relief of bronchoconstriction, but salbutamol was followed by only a 13% increase in heart rate compared with 26% after orciprenaline and 29% after isoprenaline, and only a 9% increase in systolic blood pressure compared to 13% after orciprenaline and 15% after isoprenaline.
摘要
在12名哮喘儿童的协助下，对0.5%异丙肾上腺素、2.5%奥西那林和0.5%沙丁胺醇以及一种安慰剂溶液通过Wright雾化器雾化吸入后的支气管扩张和心脏效应进行了比较。所有三种活性药物对支气管收缩的缓解效果相似，但与奥西那林后的26%和异丙肾上腺素后的29%相比，沙丁胺醇后心率仅增加13%；与奥西那林后的13%和异丙肾上腺素后的15%相比，收缩压仅增加9%。
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