Wessler S
Fed Proc. 1977 Jan;36(1):66-9.
The more widespread use of heparin as an effective antithrombotic agent would be greatly facilitated by resolution of the following issues: Clarification of the biological differences between beef and hog heparin. The development of a standard heparin molecule. The modification of heparin for oral use. The availability of a standard in vitro assay of the drug's antithrombotic potential. A meaningful assay of plasma heparin together with a determination of whether or not heparin is present in human plasma in normal and diseased states. Establishment of criterions for determining the proper dosage schedules in various pathological conditions. A reconcilation of USP and International units of heparin.
明确牛肉肝素和猪肝素之间的生物学差异；开发标准肝素分子；对肝素进行口服剂型改造；建立该药物抗血栓形成潜力的标准体外测定方法；进行有意义的血浆肝素测定，并确定正常和患病状态下人体血浆中是否存在肝素；确立在各种病理状况下确定合适给药方案的标准；协调美国药典单位和国际单位的肝素。
