Bhargava H N
Eur J Pharmacol. 1977 Jan 7;41(1):81-4. doi: 10.1016/0014-2999(77)90375-2.
Intracerebroventricular administration of methionine-enkephalin or morphine sulfate immediately prior to naloxone administration inhibited the precipitated withdrawal jumping response in mice rendered dependent on morphine by the pellet implantation method. Both methionine-enkephalin and morphine sulfate failed to inhibit withdrawal defecation and rearing behavior. Morphine sulfate was found to be four times as potent as methionine-enkephalin, on molar basis, in inhibiting the abstinence syndrome. These data provide new in vivo pharmacologic evidence for the opiate-like action of methionine-enkephalin.
在通过植入丸剂使小鼠对吗啡产生依赖性后，于注射纳洛酮之前立即进行脑室内注射甲硫氨酸脑啡肽或硫酸吗啡，可抑制小鼠的戒断性跳跃反应。甲硫氨酸脑啡肽和硫酸吗啡均未能抑制戒断性排便和竖毛行为。在抑制戒断综合征方面，以摩尔为基础计算，发现硫酸吗啡的效力是甲硫氨酸脑啡肽的四倍。这些数据为甲硫氨酸脑啡肽的阿片样作用提供了新的体内药理学证据。
