Szalay L, Bencsáth P, Takás L
Pflugers Arch. 1977 Jan 17;367(3):283-6. doi: 10.1007/BF00581367.
The effects of acute i.v. inorganic phosphate (Pi) loading were studied on nembutalized mongrel dogs previously subjected to unilateral splanchnicotomy ("renal denervation"). GFR (51Cr-EDTA) was not different on the intact and the denervated side, while urine output (V), sodium excretion (UNaV), and urinary excretion (UPiV) of inorganic phosphate of denervated kidneys were significantly increased at any plasma Pi level. Thus, tubular reabsorption of Pi in denervated kidneys was considerably depressed. Tubular transport rates of Na and Pi--as expressed in per cent of the filtered load--were positively correlated in both intact and denervated organs. Besides an impairment in tubular transport of Na a depression in the reabsorption of inorganic phosphate is brought about by renal denervation. A common mechanism of action for both Na and Pi can be supposed.
研究了急性静脉注射无机磷酸盐（Pi）对先前接受单侧内脏神经切断术（“肾去神经支配”）的戊巴比妥麻醉杂种犬的影响。完整侧和去神经支配侧的肾小球滤过率（51Cr-EDTA）无差异，而在任何血浆Pi水平下，去神经支配肾脏的尿量（V）、钠排泄量（UNaV）和无机磷酸盐的尿排泄量（UPiV）均显著增加。因此，去神经支配肾脏中Pi的肾小管重吸收明显降低。完整和去神经支配器官中，以滤过负荷百分比表示的Na和Pi的肾小管转运率呈正相关。除了肾小管对Na的转运受损外，肾去神经支配还导致无机磷酸盐重吸收降低。可以推测Na和Pi有共同的作用机制。
