Szalay L, Láng E, Bencsáth P, Mohai L, Fischer A, Takács L
Pflugers Arch. 1977 Apr 25;368(3):185-8. doi: 10.1007/BF00585194.
The renal excretion of uric acid was examined during acute i.v. urate (Ua) loading on unilaterally splanchnicotomized ("renal denervation") anaesthetized mongrel dogs. Glomerular filtration rate (GFR) in general was not different in innervated and denervated kidneys, whereas urine flow (V) and urinary excretion of sodium (UNaV) on the splanchnicotomized side were significantly increased at any plasma concentration of Ua. The excretion (UUaV) and tubular transport (TUa) of urate calculated for unit GFR were considerably increased and depressed, respectively, at normal plasma Ua level and during minor urate loading (plasma concentration up to 4.7 mg%). Above this plasma level, i.e. up to 24.6 mg%, no difference in net urate reabsorption between intact and sympathectomized organs was found. It is suggested that both reabsorption and secretion of Ua in denervated kidneys are diminished.
在对单侧内脏神经切断（“肾去神经支配”）的麻醉杂种犬进行急性静脉注射尿酸盐（Ua）负荷试验期间，检测了尿酸的肾脏排泄情况。一般来说，有神经支配和去神经支配的肾脏的肾小球滤过率（GFR）并无差异，而在内脏神经切断侧，在任何血浆尿酸盐浓度下，尿流（V）和尿钠排泄（UNaV）均显著增加。在正常血浆尿酸盐水平和轻度尿酸盐负荷（血浆浓度高达4.7mg%）期间，以单位GFR计算的尿酸排泄（UUaV）和肾小管转运（TUa）分别显著增加和降低。高于此血浆水平，即高达24.6mg%时，未发现完整器官和交感神经切除器官之间尿酸净重吸收存在差异。提示去神经支配肾脏中尿酸的重吸收和分泌均减少。
