高镁血症与精神分裂症状态下的活动及抗精神病药物治疗的关系。
Relation of hypermagnesaemia to activity and neuroleptic drug therapy in schizophrenic states.
作者信息
Brackenridge C J, Jones I H
出版信息
J Neurol Neurosurg Psychiatry. 1971 Apr;34(2):195-9. doi: 10.1136/jnnp.34.2.195.
In a study designed to explain conflicting reports of hypermagnesaemia in schizophrenia, significantly higher concentrations of plasma-magnesium were found in phenothiazine-treated schizophrenic women than in normal women of the same age. This did not apply to men. Magnesium levels were inversely related to motor activity in untreated chronic schizophrenic men in hospital as well as in patients of both sexes receiving butyrophenone or phenothiazine derivatives. The magnesium concentration fell significantly when institutionalized schizophrenic and non-schizophrenic men were placed on neuroleptic medication. It is concluded that age, sex, pharmacotherapy, and level of activity all influence the metabolism of magnesium in schizophrenic subjects.
在一项旨在解释精神分裂症患者高镁血症相互矛盾报告的研究中，发现接受吩噻嗪治疗的精神分裂症女性血浆镁浓度显著高于同龄正常女性。这一情况在男性中并不适用。在未接受治疗的住院慢性精神分裂症男性以及接受丁酰苯或吩噻嗪衍生物治疗的男女患者中，镁水平与运动活动呈负相关。当住院的精神分裂症男性和非精神分裂症男性服用抗精神病药物时，镁浓度显著下降。研究得出结论，年龄、性别、药物治疗和活动水平都会影响精神分裂症患者体内镁的代谢。
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