肾上腺对雌性大鼠体内孕酮总产量的贡献。
The contribution of the adrenal gland to the total amount of progesterone produced in the female rat.
作者信息
Fajer A B, Holzbauer M, Newport H M
出版信息
J Physiol. 1971 Apr;214(1):115-26. doi: 10.1113/jphysiol.1971.sp009422.
Abstract
- The amount of progesterone contained in both adrenal glands of a rat was similar to or larger than the amount of progesterone in the ovaries of the same rat. This was found in unstressed rats, in stressed rats and also in pregnant rats.2. After ether anaesthesia and exsanguination the adrenal progesterone content was increased by 75%; the ovarian progesterone content remained unchanged.3. In contrast, prolonged operative stress resulted in a rise in the ovarian content of progesterone and 20-dihydroprogesterone whereas the adrenal progesterone content of these rats was lower than that of unstressed rats.4. The rate at which progesterone was secreted by the adrenal glands of stressed rats was similar to the ovarian progesterone secretion rate. Rats which were kept under mild stress conditions before the experiment showed higher adrenal progesterone secretion rates.
摘要
大鼠双侧肾上腺所含孕酮量与同一只大鼠卵巢中的孕酮量相似或更多。在未受应激的大鼠、受应激的大鼠以及妊娠大鼠中均发现了这一情况。
乙醚麻醉和放血后，肾上腺孕酮含量增加了75%；卵巢孕酮含量保持不变。
相比之下，长时间手术应激导致卵巢中孕酮和20-二氢孕酮含量升高，而这些大鼠的肾上腺孕酮含量低于未受应激的大鼠。
受应激大鼠肾上腺分泌孕酮的速率与卵巢孕酮分泌速率相似。实验前处于轻度应激条件下的大鼠肾上腺孕酮分泌速率更高。
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