Wright V, Haslock D I, Dowson D, Seller P C, Reeves B
Br Med J. 1971 May 15;2(5758):370-3. doi: 10.1136/bmj.2.5758.370.
Silicone 300 has been evaluated as an artificial lubricant in osteoarthrotic joints by means of a pilot study in five inpatients and a control trial of 25 outpatients with 40 osteoarthrotic knees. Sequential analysis showed a significant benefit from saline compared with silicone at one week follow-up and no significant difference at one month.Measurement of stiffness with a knee arthrograph showed no difference in reduction of stiffness between the two substances. In a study of 18 rabbits there was no evidence that silicone was retained in the joint cavity for longer than 48 hours. There was a failure of clearance of iodinated serum albumin for as long as three to four days after the injection of silicone, suggesting some obstruction to lymphatic outflow. Experimentally produced cartilaginous defects did not heal quicker with the injection of silicone into the joint.
通过对5名住院患者进行的初步研究以及对25名患有40个骨关节炎膝关节的门诊患者进行的对照试验，已对硅酮300作为骨关节炎关节中的人工润滑剂进行了评估。序贯分析表明，在一周随访时，与硅酮相比，生理盐水有显著益处，而在一个月时无显著差异。用膝关节造影测量僵硬程度显示，两种物质在减轻僵硬方面没有差异。在一项对18只兔子的研究中，没有证据表明硅酮在关节腔内的留存时间超过48小时。注射硅酮后，碘化血清白蛋白的清除长达三到四天都存在障碍，这表明淋巴流出存在一些阻塞。通过实验制造的软骨缺损，向关节内注射硅酮后愈合并未加快。
