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1
Estimation of urinary 5-hydroxytryptamine-O-glucuronide, a metabolite of endogenous 5-hydroxytryptamine in sheep.绵羊体内内源性5-羟色胺的代谢产物——尿5-羟色胺-O-葡萄糖醛酸苷的测定
Br J Pharmacol. 1971 Mar;41(3):530-9. doi: 10.1111/j.1476-5381.1971.tb08051.x.
2
5-hydroxytryptamine metabolism in sheep.绵羊体内5-羟色胺的代谢
Br J Pharmacol. 1971 Jun;42(2):273-80. doi: 10.1111/j.1476-5381.1971.tb07108.x.
3
Estimation of 5-hydroxyindolylacetic acid in sheep urine.绵羊尿液中5-羟吲哚乙酸的测定
Clin Chim Acta. 1970 Dec;30(3):559-65. doi: 10.1016/0009-8981(70)90245-7.
4
Biliary excretion and enterohepatic circulation of (14C)5-hydroxytryptamine in normal and cirrhotic rats.
Gastroenterology. 1974 Oct;67(4):700-8.
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Studies of the kinetics of 14C-5-hydroxytryptamine metabolism in the rat.
Ann Med Exp Biol Fenn. 1968;46(3):490-7.
6
Uptake and metabolism of 5-hydroxytryptamine by the isolated perfused rat liver.
Am J Physiol. 1968 Sep;215(3):611-9. doi: 10.1152/ajplegacy.1968.215.3.611.
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Free and conjugated serotonin excretion in carcinoid syndrome.类癌综合征中游离和结合血清素的排泄
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5-Hydroxytryptophol conjugation in man: influence of alcohol consumption and altered serotonin turnover.人体内5-羟色醇的结合：酒精摄入及血清素代谢改变的影响
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Excretion of 5-hydroxyindoleacetic acid conjugates in neurocirculatory asthenia and after injection of 5-hydroxytryptamine.5-羟吲哚乙酸结合物在神经循环衰弱症及注射5-羟色胺后的排泄情况。
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Identification of 5-hydroxytryptophol as a serotonin metabolite in man.鉴定5-羟色胺醇作为人体中的一种血清素代谢物。
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引用本文的文献

1
5-hydroxytryptamine metabolism in sheep.绵羊体内5-羟色胺的代谢
Br J Pharmacol. 1971 Jun;42(2):273-80. doi: 10.1111/j.1476-5381.1971.tb07108.x.

本文引用的文献

1
Metabolism of d-glucuronolactone in mammalian systems. Identification of d-glucaric acid as a normal constituent of urine.d-葡糖醛酸内酯在哺乳动物系统中的代谢。鉴定d-葡萄糖二酸为尿液的正常成分。
Biochem J. 1963 Jan;86(1):77-86. doi: 10.1042/bj0860077.
2
Measurement of urinary tryptamine, tyramine and serotonin.尿中色胺、酪胺和血清素的测定。
Methods Med Res. 1961;9:169-74.
3
The estimation of 5-hydroxytryptamine (serotonin) in biological tissues.生物组织中5-羟色胺（血清素）的测定。
J Biol Chem. 1955 Jul;215(1):337-44.
4
GLUCURONOSYL TRANSFERASE ACTIVITY IN LIVERS OF RAT, DOG, AND SHEEP.大鼠、狗和绵羊肝脏中的葡萄糖醛酸转移酶活性。
Proc Soc Exp Biol Med. 1964 Jul;116:613-7. doi: 10.3181/00379727-116-29320.
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Properties of limpet beta-glucuronidase.帽贝β-葡萄糖醛酸酶的特性。
Biochem J. 1957 Jan;65(1):203-8. doi: 10.1042/bj0650203.
6
A procedure increasing the specificity of the Jaffe reaction for the determination of creatine and creatinine in urine and plasma.一种提高Jaffe反应特异性的方法，用于测定尿液和血浆中的肌酸和肌酐。
Clin Chim Acta. 1956 May-Jun;1(3):210-24. doi: 10.1016/0009-8981(56)90067-5.
7
A fluorescence test for serotonin and other tryptamines.
Nature. 1953 Oct 24;172(4382):772. doi: 10.1038/172772a0.
8
The sulphatase of ox liver. I. The complex nature of the enzyme.牛肝硫酸酯酶。I. 该酶的复合性质。
Biochem J. 1953 Jan;53(1):12-5. doi: 10.1042/bj0530012.
9
The preparation and properties of beta-glucuronidase. IV. Inhibition by sugar acids and their lactones.β-葡萄糖醛酸酶的制备及其性质。IV. 糖酸及其内酯的抑制作用。
Biochem J. 1952 Nov;52(3):464-72. doi: 10.1042/bj0520464.
10
Isolation of serotonin-O-sulfate from human urine.从人尿中分离5-羟色胺-O-硫酸盐。
Clin Chim Acta. 1966 Mar;13(3):380-2. doi: 10.1016/0009-8981(66)90218-x.

绵羊体内内源性5-羟色胺的代谢产物——尿5-羟色胺-O-葡萄糖醛酸苷的测定

Estimation of urinary 5-hydroxytryptamine-O-glucuronide, a metabolite of endogenous 5-hydroxytryptamine in sheep.

作者信息

Bartlet A L, Gilbert F M

出版信息

Br J Pharmacol. 1971 Mar;41(3):530-9. doi: 10.1111/j.1476-5381.1971.tb08051.x.

DOI:10.1111/j.1476-5381.1971.tb08051.x
PMID:5576258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1702862/
Abstract
  1. 5-Hydroxytryptamine-O-glucuronide has been extracted from sheep urine and characterized by its chemical reactions and R(F) values on paper chromatograms.2. 5-Hydroxytryptamine-O-glucuronide in urine was separated from an inhibitor of beta-glucuronidase using an anion exchange resin, and then estimated by measurement of the 5-hydroxytryptamine (5-HT) liberated on incubation with beta-glucuronidase.3. About 20% of the 5-hydroxyindoles found in sheep urine was 5-HT conjugated with glucuronic acid (1.18+/-0.08 mg 5-HT/24 h, thirty experiments).4. Sheep urine also contained free 5-HT (0.35+/-0.04 mg/24 h, thirty experiments) and 5-hydroxyindolylacetic acid (4.43+/-0.33 mg/24 h, thirty experiments).5. 5-Hydroxytryptamine-O-sulphate was not found in sheep urine.
摘要

  1. 5-羟色胺-O-葡萄糖醛酸已从绵羊尿液中提取出来，并通过其化学反应和纸色谱上的R(F)值进行了表征。

  2. 使用阴离子交换树脂将尿液中的5-羟色胺-O-葡萄糖醛酸与β-葡萄糖醛酸酶抑制剂分离，然后通过测量与β-葡萄糖醛酸酶孵育时释放的5-羟色胺（5-HT）来进行估算。

  3. 在绵羊尿液中发现的5-羟吲哚约20%是与葡萄糖醛酸结合的5-HT（1.18±0.08毫克5-HT/24小时，三十次实验）。

  4. 绵羊尿液中还含有游离的5-HT（0.35±0.04毫克/24小时，三十次实验）和5-羟吲哚乙酸（4.43±0.33毫克/24小时，三十次实验）。

  5. 在绵羊尿液中未发现5-羟色胺-O-硫酸盐。