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老年患者的择期脾切除术。

Elective splenectomy in the elderly patient.

作者信息

Deckinga B G, Printen K J

出版信息

Am Surg. 1977 Apr;43(4):195-9.

PMID:557944
Abstract

This report reviews 10 years' experience with elective splenectomy in patients over 55 years of age. Of 55 patients, 25 were over the age of 65. The majority of splenectomies (41) were performed for hematological disorders exclusive of lymphoma, but including ITP, hypersplenism (both primary and secondary), Felty's syndrome and myeloid metaplasia. Sixty-eight per cent of these patients responded to splenectomy with sustained elevation of platelet counts while 70 per cent responded to sustained elevation of leukocyte counts. Sixteen of the hematological patients received a preoperative trial of steroid therapy in an attempt to alleviate leukopenia or thrombocytopenia with a 37.5 per cent (6 of 16) success rate. There was no correlation between the response to preoperative steroid therapy and response to splenectomy. These data correspond favorably to previous published material in the younger aged patients. There was no difference in the postoperative complication rate related to drainage or nondrainage of the splenic bed. However, eight other complications occurred for a morbidity rate of 14.5 per cent in addition to complications related to drainage of the splenic bed (8%). A 9 per cent (5 of 55) mortality rate was related to the patients' pre-existing diseases and appears acceptable in light of hematological response rate and quoted mortality rates for splenectomy over age 65.

摘要

本报告回顾了55岁以上患者择期脾切除术的10年经验。55例患者中,25例年龄超过65岁。大多数脾切除术(41例)是针对非淋巴瘤的血液系统疾病进行的,但包括特发性血小板减少性紫癜、脾功能亢进(原发性和继发性)、费尔蒂综合征和骨髓化生。这些患者中有68%的人脾切除术后血小板计数持续升高,70%的人白细胞计数持续升高。16例血液系统疾病患者接受了术前类固醇治疗试验,试图缓解白细胞减少或血小板减少,成功率为37.5%(16例中的6例)。术前类固醇治疗的反应与脾切除术的反应之间没有相关性。这些数据与之前发表的关于年轻患者的材料相符。脾床引流与否与术后并发症发生率没有差异。然而,除了与脾床引流相关的并发症(8%)外,还发生了其他8例并发症,发病率为14.5%。9%(55例中的5例)的死亡率与患者先前存在的疾病有关,鉴于血液学反应率和报道的65岁以上脾切除术死亡率,这一死亡率似乎是可以接受的。

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